Corneal Storage for 14 days.
CORNISOL is a sterile, 20 ml buffered corneal preservation medium supplemented with chondroitin sulfate (Membrane stabilizer), recombinant human insulin (Metabolism enhancer), Dextran (Osmotic agent), stabilized L-glutamine, ATP precursors, vitamins, trace elements, gentamicin, streptomycin and pH indicator.
- Clear optical bottom vial guarantees complete microscopic evaluation without transferring tissue to viewing chamber .
- Enhances Endothelial and Epithelial cell preservation.
- Reduces corneal thickness and folds.
- Enhanced stability of medium is shown by stability study results.
- Dual antibiotics reduces the risk of infection rate.
- No bovine derived components to avoid BSE/TSE prion transmission.
- Human cornea can be stored up to 14 days under refrigeration.
- pH color indicator helps in detection of unacceptable deviation in pH.
- Economical corneal storage media for eye banks.
CORNISOL is a corneal storage solution for storage of human cornea suitable for keratoplasty for up to 14 days under refrigeration (2-8 °C).
1) SUITABLE PH RANGE:
Reference: Effect of pH change on Corneas during storage at 4 °C. EBAA Abstract, university of Southern California, Doheny Eye Institute, Los Angeles, CA, U.S.A.
2) ENDOTHELIAL CELL COUNT:
Endothelial cell density, polymegathism and pleomorphism were performed by specular microscopy at day 1, 4, 5, 7, 10, 14. Endothelial cell count remained similar throughout 14 days
Specular images: Day 1 (2670 cells/mm2) & Day 14 (3082 cells/mm2).
Courtesy: SigtlifeŽ, USA
Reference: Teresa LM, Geroski GH. Viability of human corneal endothelium following Optisol GS storage. Arch. Ophthalmol 1995.
3) CORNEAL THICKNESS:
Corneal thickness was maintained at comparable to Optisol GS through out 14 Days storage period. The ability of Cornisol to maintain the hexagonal shape of the corneal endothelial cells is equivalent to Optisol GS. High quality Chondroitin sulfate used in the formulation plays major role in the maintenance of endothelial cell integrity.
Reference: Stocker, FW. The endothelium of the cornea and its clinical implications. Trans Am Ophthalmol Soc. 51:669-789. 1953