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DESCRIPTION
AUROGREEN (active ingredient Indocyanine green–ICG) is a diagnostic dye used mainly
for ophthalmic angiography.
INDICATIONS
• Age-related macular degeneration
• Choroidal neo vascularisation (CNV)
• Central serous choroido retinopathy
• Pigment epithelial detachment (PED)
• Intraocular tumors and choroiditis
CONTRAINDICATIONS
1. As in vitro experiments have shown that indocyanine green displaces bilirubin from its
protein binding, AUROGREEN should not been used in premature infants or neonates in
whom an exchange transfusion is indicated on account of hyperbilirubinaemia.
2. Should not been used in patients allergic to iodine unless special precautions are taken.
3. Should not been performed in patients who are uremic unless appropriate emergency
equipments are readily available.
INTERACTIONS WITH OTHER DRUGS
Concomitant use of certain drugs and injectables can alter the absorbance. Injectables
containing sodium disulphite particularly in combination with heparin reduce the
absorption.
The following drugs reduce the absorption–anticonvulsants, disulphite compounds,
haloperidol, heroin, meperidine, metamizol, methadone, morphium, nitrofurantoin,
opium alkaloids, phenobarbital, phenylbutazone.
Drugs like cyclopropane, probenicid and rifamycin increase the absorption.
WARNINGS & PRECAUTIONS
• Do not dilute with solutions containing salts (saline, Ringer's solution, etc.).
• Dissolve the dye as per instructions given in the leaflet. (Read directions).
• For single use only.
• Do not resterilize.
• Do not autoclave.
• Aurogreen should be used in pregnancy only after carefully considering the benefits
and risks.
TOXICITY & SIDE EFFECT
Aurogreen is a safe dye with only a minor side-effect like iodide allergy reported with its
clinical use. It is safer than fluorescein sodium. Vomiting and nausea are extremely
uncommon during ICG angiography. No complications were reported in a study using
intravenous ICG doses of 150 to 200 mg.
SUPPLY
Aurogreen is available as a lyophilized sterile powder of 25 mg for ophthalmic angiography.
DIRECTIONS
• Reconstitute with 5ml of sterile water for injection and shake well for at least 3 minutes
for complete dissolution of the dye, resulting in a final concentration of 5 mg dye/ ml of
water (i.e. 0.5% solution)
• The reconstituents (dye solution) should be withdrawn from the vial through the sterile
yringe filter (0.2 micron) using sterile syringe and 21 gauge needle.
The purpose of using sterile syringe filter is:
(i) to avoid any undissolved dye in the solution due to inadequate shaking/dissolution which cannot be observed visually since the dye solution is dark green in colour
(ii) any other cross-contamination at the time of reconstitution which gets through
into the syringe.
• Then remove the syringe filter and the 21 gauge needle from the syringe and dispose.
• Attach fresh sterile 23 gauge needle into the syringe and inject into the patient
• Use the reconstituents within ten hours
• Store between 2° C and 35°C
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